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J Cancer Res Clin Oncol. 1990;116(5):434-8.

Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes.

Author information

  • 1Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Sonderforschungsbereich 234 (SFB 234), Universität Regensburg, Federal Republic of Germany.

Abstract

The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.

PMID:
2229132
[PubMed - indexed for MEDLINE]
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