Display Settings:

Format

Send to:

Choose Destination
Aging (Albany NY). 2012 Jan;4(1):13-27.

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.

Author information

  • 1Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.

Abstract

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.

PMID:
22291164
[PubMed - indexed for MEDLINE]
PMCID:
PMC3292902
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Impact Journals, LLC Icon for PubMed Central
    Loading ...
    Write to the Help Desk