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    Clin Infect Dis. 2012 Apr;54(7):968-71. Epub 2012 Jan 30.

    Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts.

    Cobat A, Barrera LF, Henao H, Arbeláez P, Abel L, García LF, Schurr E, Alcaïs A.

    Source

    McGill Centre for the Study of Host Resistance, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.

    Abstract

    The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.

    PMID:
    22291100
    [PubMed - in process]
    PMCID:
    PMC3297651
    [Available on 2013/4/1]

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