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Cancer J. 2012 Jan-Feb;18(1):89-99. doi: 10.1097/PPO.0b013e318244d8ae.

Novel delivery strategies for glioblastoma.

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  • 1Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.


Brain tumors--particularly glioblastoma multiforme--pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insufficient with nearly universal recurrence. A major reason for this failure is the difficulty of delivering therapeutic agents to the brain: better delivery approaches are needed to improve treatment. In this article, we summarize recent progress in drug delivery to the brain, with an emphasis on convection-enhanced delivery of nanocarriers. We examine the potential of new delivery methods to permit novel drug- and gene-based therapies that target brain cancer stem cells and discuss the use of nanomaterials for imaging of tumors and drug delivery.

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