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Med Sci (Paris). 2012 Jan;28(1):69-75. doi: 10.1051/medsci/2012281019. Epub 2012 Jan 27.

[IAPs: a central element in the NF-κB activating signaling pathway].

[Article in French]

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  • 1Inserm UMR 866, Faculté de Médecine, Université de Bourgogne, 7, Boulevard Jeanne d'Arc, 21079 Dijon Cedex, France.


The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

© 2012 médecine/sciences – Inserm / SRMS.

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