Format

Send to:

Choose Destination
See comment in PubMed Commons below
Med Sci (Paris). 2012 Jan;28(1):69-75. doi: 10.1051/medsci/2012281019. Epub 2012 Jan 27.

[IAPs: a central element in the NF-κB activating signaling pathway].

[Article in French]

Author information

  • 1Inserm UMR 866, Faculté de Médecine, Université de Bourgogne, 7, Boulevard Jeanne d'Arc, 21079 Dijon Cedex, France.

Abstract

The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

© 2012 médecine/sciences – Inserm / SRMS.

PMID:
22289833
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for EDP Sciences
    Loading ...
    Write to the Help Desk