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    J Chem Biol. 2011 Jul;4(3):109-16. Epub 2011 Jan 29.

    Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

    Kuhnert N, Dairpoosh F, Jaiswal R, Matei M, Deshpande S, Golon A, Nour H, Karaköse H, Hourani N.

    Source

    School of Engineering and Science, Centre for Nano- and functional materials, Jacobs University Bremen, Campus Ring 8, 28759 Bremen, Germany.

    Abstract

    Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose-response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.

    PMID:
    22287993
    [PubMed - in process]
    PMCID:
    PMC3124628
    Free PMC Article

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