Design, synthesis and biological evaluation of noncovalent inhibitors of human CD38 NADase

ChemMedChem. 2012 Feb 6;7(2):223-8. doi: 10.1002/cmdc.201100487. Epub 2012 Jan 3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-ribosyl Cyclase 1 / antagonists & inhibitors*
  • ADP-ribosyl Cyclase 1 / metabolism
  • Binding Sites
  • Catalytic Domain
  • Drug Design*
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Furans / chemical synthesis
  • Furans / chemistry*
  • Furans / pharmacology
  • Humans
  • Phenylurea Compounds / chemical synthesis
  • Phenylurea Compounds / chemistry*
  • Phenylurea Compounds / pharmacology
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Furans
  • Phenylurea Compounds
  • ADP-ribosyl Cyclase 1