Z Rheumatol. 2012 Jan;71(1):78-82.

[Rheumatoid arthritis and multiple myeloma as comorbidity. Is tocilizumab a therapy option?].

[Article in German]

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Klinik Innere Medizin IV (Rheumatologie, klinische Immunologie und Nephrologie), HSK, Dr.-Horst-Schmidt-Kliniken GmbH, Ludwig-Erhard-Str. 100, 65199, Wiesbaden, Deutschland. norbert.schuetz@hsk-wiesbaden.de

Abstract

Multiple myeloma (MM) is a disease of the elderly with an incidence of 4/100,000 per year and can occur as a comorbidity especially in elderly patients with rheumatoid arthritis (RA). For MM and also for RA interleukin-6 (IL-6) is a pathogenetically important cytokine in both disease events. This article presents the case of a female patient who achieved sustained remission of RA and stabilization of MM with quantitative reduction of paraprotein by treatment with tocilizumab. The question whether tocilizumab represents a meaningful treatment approach for treatment of RA when MM is also present will be discussed.

PMID:: 22286359; [PubMed - indexed for MEDLINE]

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