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    Leuk Res. 2012 Jul;36(7):868-75. Epub 2012 Jan 29.

    Obesity but not overweight increases the incidence and mortality of leukemia in adults: A meta-analysis of prospective cohort studies.

    Castillo JJ, Reagan JL, Ingham RR, Furman M, Dalia S, Merhi B, Nemr S, Zarrabi A, Mitri J.

    Source

    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

    Abstract

    The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associated with a relative risk (RR) of 1.26 (95% CI 1.17-1.37; p<0.001) for leukemia incidence and 1.29 (95% CI 1.11-1.49; p=0.001) for mortality. Obesity was also associated with an increased incidence of acute myeloid leukemia (RR 1.53, 95% CI 1.26-1.85; p<0.001), chronic lymphocytic leukemia (RR 1.17, 95% CI 1.08-1.27; p<0.001), chronic myeloid leukemia (RR 1.16, 95% CI 1.04-1.30; p=0.007) and acute lymphoblastic leukemia (RR 1.62, 95% CI 1.12-2.32; p=0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men.

    Copyright © 2012 Elsevier Ltd. All rights reserved.

    PMID:
    22285508
    [PubMed - in process]

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