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Hepatogastroenterology. 2012 Jun;59(116):1241-4. doi: 10.5754/hge11881.

Clinicopathological significance of E-cadherin, β-catenin and epidermal growth factor receptor expression in intrahepatic cholangiocarcinoma.

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  • 1Department of Pathology, Yeungnam University College of Medicine, Daegu, South Korea.



The study investigated the pathogenetic role of e-cadherin, β-catenin, and epidermal growth factor receptor (EGFR) in cholangiocarcinoma (CC) and analyzed the correlation with clinicopathological factors.


Eighty three patients with CC who had undergone resection were studied. The expression of E-cadherin, β-catenin and EGFR was examined by immunohistochemistry.


The down-regulation of E-cadherin and β-catenin was identified in 43/83 patients (51.8%) and 32/83 patients (38.6%), respectively. EGFR expression occurred in 46 of 83 patients (55.4%). The reduced membranous expression of E-cadherin was correlated with poor histological differentiation. The reduced membranous expression of β-catenin was correlated with higher tendency of vascular invasion and was more frequent in males. EGFR was more expressed in poorly differentiated CC. The reduced membranous expression of E-cadherin was significantly correlated with reduced expression of β-catenin.


The reduced expression of E-cadherin and β-catenin and EGFR over expression seems to be correlated with tumor differentiation and tumor progression than tumor invasion and tumor proliferation.

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