Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Background/Aims: The study investigated the pathogenetic role of e-cadherin, β-catenin, and epidermal growth factor receptor (EGFR) in cholangiocarcinoma (CC) and analyzed the correlation with clinicopathological factors. Methodology: Eighty three patients with CC who had undergone resection were studied. The expression of E-cadherin, β-catenin and EGFR was examined by immunohistochemistry. Results: The down-regulation of E-cadherin and β-catenin was identified in 43/83 patients (51.8%) and 32/83 patients (38.6%), respectively. EGFR expression occurred in 46 of 83 patients (55.4%). The reduced membranous expression of E-cadherin was correlated with poor histological differentiation. The reduced membranous expression of β-catenin was correlated with higher tendency of vascular invasion and was more frequent in males. EGFR was more expressed in poorly differentiated CC. The reduced membranous expression of E-cadherin was significantly correlated with reduced expression of β-catenin. Conclusions: The reduced expression of E-cadherin and β-catenin and EGFR over expression seems to be correlated with tumor differentiation and tumor progression than tumor invasion and tumor proliferation.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on