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Dig Liver Dis. 2012 Jul;44(7):585-8. doi: 10.1016/j.dld.2011.12.019. Epub 2012 Jan 26.

"PancPro" as a tool for selecting families eligible for pancreatic cancer screening: an Italian study of incident cases.

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  • 1Gastroenterology Unit, Pisa University Hospital, Italy. giulialeonardi@alice.it

Abstract

BACKGROUND:

PancPRO is a computer program that estimates the risk of pancreatic cancer for asymptomatic individuals based on a genetic model of susceptibility and the familial incidence of cancer.

AIM:

To evaluate the distribution of the familial risk in a series of incident cases of pancreatic adenocarcinoma.

MATERIALS AND METHODS:

The lifetime risk of pancreatic cancer was calculated by PancPro for a hypothetical 40-year-old son of 570 consecutive probands with pancreatic cancer.

RESULTS:

The 570 risk values were included between 1% and 13%. The distribution was bimodal, with the antimode located at risk=7.5%. Considering a 10-fold risk over the general population as a threshold for including a subject in a surveillance program, 19 families (3.3%) would be selected, totalling 92 first-degree relatives with age >40 years.

CONCLUSIONS:

PancPro is a valid instrument to rank families based on risk of pancreatic cancer.

Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

PMID:
22281375
[PubMed - indexed for MEDLINE]
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