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    Cancer Lett. 2012 Aug 28;321(2):137-43. Epub 2012 Jan 25.

    Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells.

    Yang X, Wang J, Zhou Y, Wang Y, Wang S, Zhang W.

    Source

    Beijing Obstetrics and Gynecology Hospital, Capital University of Medical Sciences, Beijing 100026, China.

    Abstract

    Cisplatin can induce apoptosis in ovarian cancer cells through the mitochondrial death pathway, and dysregulation of this pathway contributes to cisplatin resistance in ovarian cancer cells. Here we show that cisplatin induces mitochondrial proteins such as Smac/DIABLO, Cytochrome c, and HrtA2/Omi release to the cytosol and apoptosis in cisplatin-sensitive, but not -resistant ovarian cancer cells. Bax translocation to mitochondria is required for mitochondrial protein release and cisplatin-induced apoptosis in human ovarian cancer cells. Hsp70 is highly expressed in cisplatin-resistant cells. Hsp70 promotes chemoresistance, in part, by blocking Bax translocation to the mitochondria and mitochondrial protein release to cytosol in human ovarian cancer cells.

    Copyright © 2012. Published by Elsevier Ireland Ltd.

    PMID:
    22281241
    [PubMed - in process]

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