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Laryngoscope. 2012 May;122(5):1040-2. doi: 10.1002/lary.23209. Epub 2012 Jan 24.

Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.

Author information

  • 1Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. netagil@mail.nih.gov

Abstract

OBJECTIVES/HYPOTHESIS:

Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC.

STUDY DESIGN:

Case-control study.

METHODS:

We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odds ratios and compute P values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method.

RESULTS:

We did not find a significant association between rs1562430, rs1447295, or rs6983267 and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P = .003, and 12 other SNPs were associated with PTC risk at P < .05. However, no SNPs remained significant after FDR correction.

CONCLUSIONS:

Our findings do not support a strong association between SNPs in the 8q24 chromosomal region and risk of sporadic PTC, but several SNPs with small effects might exist.

Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

PMID:
22275265
[PubMed - indexed for MEDLINE]
PMCID:
PMC3408055
Free PMC Article

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