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J Cell Biochem. 2012 May;113(5):1470-7. doi: 10.1002/jcb.24074.

Tumor suppressor function of RUNX3 in breast cancer.

Author information

  • 1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. lfchen@life.illinois.edu

Abstract

Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 is associated with the initiation and progression of breast cancer. Female Runx3(+/-) mice spontaneously develop ductal carcinoma, and overexpression of RUNX3 inhibits the proliferation, tumorigenic potential, and invasiveness of breast cancer cells. This review is intended to summarize these findings and discuss the tumor suppressor function of RUNX3 in breast cancer.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22275124
[PubMed - indexed for MEDLINE]
PMCID:
PMC3337355
Free PMC Article
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