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Antimicrob Agents Chemother. 2012 Apr;56(4):2201-4. doi: 10.1128/AAC.05521-11. Epub 2012 Jan 23.

In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization.

Author information

  • 1Baylor College of Medicine, Houston, Texas, USA. mdmansouri@aol.com

Abstract

Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

PMID:
22271864
[PubMed - indexed for MEDLINE]
PMCID:
PMC3318368
Free PMC Article
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