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Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:46-53. doi: 10.1002/dmrr.2234.

Diabetes and foot infection: more than double trouble.

Author information

  • 1Department of Diabetology and Nutritional Diseases, Medical Centre, University Hospital of Nîmes, 30240, Le Grau du Roi, France. jean.louis.richard@chu-nimes.fr

Abstract

BACKGROUND:

Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them.

METHODS:

This article reviews these factors, in the light of data from the literature and from our own results.

RESULTS:

DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms.

CONCLUSION:

The development of new tools from molecular biology is a critical step to better understand and manage these infections.

Copyright © 2012 John Wiley & Sons, Ltd.

PMID:
22271723
[PubMed - indexed for MEDLINE]
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