Send to:

Choose Destination
See comment in PubMed Commons below
Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:46-53. doi: 10.1002/dmrr.2234.

Diabetes and foot infection: more than double trouble.

Author information

  • 1Department of Diabetology and Nutritional Diseases, Medical Centre, University Hospital of Nîmes, 30240, Le Grau du Roi, France.



Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them.


This article reviews these factors, in the light of data from the literature and from our own results.


DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms.


The development of new tools from molecular biology is a critical step to better understand and manage these infections.

Copyright © 2012 John Wiley & Sons, Ltd.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk