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AIDS. 2012 Mar 27;26(6):765-8. doi: 10.1097/QAD.0b013e3283514350.

Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.

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  • 1Department of Oncology and Surgical Sciences, AIDS Reference Centre, University of Padova, Padua, Italy.


Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 -44C > G, -52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFβ1 -44CG genotype and DEFβ1 [G;G] haplotype correlated with a better clinical outcome.

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