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    AIDS. 2012 Mar 27;26(6):765-8.

    Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children.

    Freguja R, Gianesin K, Del Bianco P, Malacrida S, Rampon O, Zanchetta M, Giaquinto C, De Rossi A.

    Source

    Department of Oncology and Surgical Sciences, AIDS Reference Centre, University of Padova, Padua, Italy.

    Abstract

    Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 -44C > G, -52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFβ1 -44CG genotype and DEFβ1 [G;G] haplotype correlated with a better clinical outcome.

    PMID:
    22269973
    [PubMed - in process]

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