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Generation of human endothelin by cathepsin E.
Department of Biochemistry, University of Wales College of Cardiff, UK.
Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.
PMID: 2226872 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Crystal structure of human pepsin and its complex with pepstatin.
Fujinaga M, Chernaia MM, Tarasova NI, Mosimann SC, James MN.
Protein Sci. 1995 May; 4(5):960-72.
[Protein Sci. 1995]
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Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E.
Robinson PS, Lees WE, Kay J, Cook ND.
Biochem J. 1992 Jun 1; 284 ( Pt 2):407-9.
[Biochem J. 1992]
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The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.
Kaw S, Hecker M, Vane JR.
Proc Natl Acad Sci U S A. 1992 Aug 1; 89(15):6886-90.
[Proc Natl Acad Sci U S A. 1992]