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    FEBS Lett. 1990 Oct 29;273(1-2):99-102.

    Generation of human endothelin by cathepsin E.

    Lees WE, Kalinka S, Meech J, Capper SJ, Cook ND, Kay J.

    Department of Biochemistry, University of Wales College of Cardiff, UK.

    Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.

    PMID: 2226872 [PubMed - indexed for MEDLINE]

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