Cancer Lett. 2012 Jul 1;320(1):40-7. Epub 2012 Jan 20.

MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins.

Chen H, Lin YW, Mao YQ, Wu J, Liu YF, Zheng XY, Xie LP.

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Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Abstract

Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of T24 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer.

PMID:: 22266187; [PubMed - in process]

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MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins.

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