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Dev Cell. 2012 Jan 17;22(1):12-23. doi: 10.1016/j.devcel.2011.12.003.

Expanding the morphogenetic repertoire: perspectives from the Drosophila egg.

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  • 1Department of Molecular & Cell Biology, 379 Life Sciences Addition #3200, University of California, Berkeley, Berkeley, CA 94720-3200, USA.


Tissue and organ architectures are incredibly diverse, yet our knowledge of the morphogenetic behaviors that generate them is relatively limited. Recent studies have revealed unexpected mechanisms that drive axis elongation in the Drosophila egg, including an unconventional planar polarity signaling pathway, a distinctive type of morphogenetic movement termed "global tissue rotation," a molecular corset-like role of extracellular matrix, and oscillating basal cellular contractions. We review here what is known about Drosophila egg elongation, compare it to other instances of morphogenesis, and highlight several issues of general developmental relevance.

Copyright © 2012 Elsevier Inc. All rights reserved.

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