My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    AIDS Res Hum Retroviruses. 2012 Mar 6. [Epub ahead of print]

    No Increase of Drug-Resistant HIV Type 1 Prevalence Among Drug-Naive Individuals in Northern Vietnam.

    Tran VT, Ishizaki A, Nguyen CH, Hoang HT, Pham HV, Bi X, Pham TV, Ichimura H.

    Source

    1 Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University , Kanazawa, Japan .

    Abstract

    Abstract We reported previously that the prevalence of drug-resistant HIV-1 among antiretroviral therapy (ART)-naive individuals in Northern Vietnam was 2.9% in 2007 and 6.2% in 2008. To investigate the continuing trend of prevalence, we collected plasma samples from 958 individuals in Hai Phong and Hanoi in 2009, extracted viral RNA from HIV-1 antibody-positive samples, and analyzed them genetically. HIV-1 antibody prevalence was 26.8% in injecting drug users (n=302), 13.4% in female sex workers (n=284), 0.5% in blood donors (n=206), and 0.6% in pregnant women (n=166). All HIV-1 strains were CRF01_AE. Nonnucleoside reverse-transcriptase inhibitor resistance mutations were found in two (2.0%) of the 102 successfully analyzed cases (one case with the Y181C and one with the K101E). No nucleoside reverse-transcriptase inhibitor resistance or protease inhibitor resistance mutations were detected. The prevalence of circulating ART-resistant HIV-1 in Northern Vietnam did not increase from 2007 to 2009, although the rate of ART coverage did increase.

    PMID:
    22264087
    [PubMed - as supplied by publisher]

    LinkOut - more resources

    Full Text Sources

      Supplemental Content

      Icon for Mary Ann Liebert, Inc.

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk