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J Virol. 2012 Mar;86(6):2900-10. doi: 10.1128/JVI.05738-11. Epub 2012 Jan 18.

Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion.

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  • 1Institute of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark.


Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

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