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Pediatr Res. 2012 Feb;71(2):199-204. doi: 10.1038/pr.2011.31. Epub 2011 Dec 21.

Depression of whole-brain oxygen extraction fraction is associated with poor outcome in pediatric traumatic brain injury.

Author information

  • 1Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.

Abstract

INTRODUCTION:

Traumatic brain injury (TBI) is a leading cause of death and disability in children. Metabolic failure is an integral component of the pathological aftermath of TBI. The oxygen extraction fraction (OEF) is a valuable parameter for characterization and description of metabolic abnormalities; however, OEF measurement has required either invasive procedures or the use of ionizing radiation, which significantly limits its use in pediatric research.

RESULTS:

Patients with TBI had depressed OEF levels that correlated with the severity of injury. In addition, the OEF measured within 2 weeks of injury was predictive of patient outcome at 3 mo after injury. In pediatric TBI patients, low OEF-a marker of metabolic dysfunction-correlates with the severity of injury and outcome.

DISCUSSION:

Our findings support previous literature on the role of metabolic dysfunction after TBI.

METHODS:

Using a recently developed magnetic resonance (MR) technique for the measurement of oxygen saturation, we determined the whole-brain OEF in both pediatric TBI patients and in healthy controls. Injury and outcome were classified using pediatric versions of the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale-Extended (GOS-E), respectively.

PMID:
22258132
[PubMed - indexed for MEDLINE]
PMCID:
PMC3593145
Free PMC Article

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