Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
    Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7610-3. doi: 10.1109/IEMBS.2011.6091875.

    Generation of intervention strategy for a genetic regulatory network represented by a family of Markov Chains.

    Source

    Electrical and Computer Engineering Department, Texas Tech University, Lubbock, TX 79409, USA. noah.berlow@ttu.edu

    Abstract

    Genetic Regulatory Networks (GRNs) are frequently modeled as Markov Chains providing the transition probabilities of moving from one state of the network to another. The inverse problem of inference of the Markov Chain from noisy and limited experimental data is an ill posed problem and often generates multiple model possibilities instead of a unique one. In this article, we address the issue of intervention in a genetic regulatory network represented by a family of Markov Chains. The purpose of intervention is to alter the steady state probability distribution of the GRN as the steady states are considered to be representative of the phenotypes. We consider robust stationary control policies with best expected behavior. The extreme computational complexity involved in search of robust stationary control policies is mitigated by using a sequential approach to control policy generation and utilizing computationally efficient techniques for updating the stationary probability distribution of a Markov chain following a rank one perturbation.

    PMID:
    22256100
    [PubMed - indexed for MEDLINE]

      Supplemental Content

      Icon for IEEE Engineering in Medicine and Biology Society

      Save items

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk