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Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5555-8. doi: 10.1109/IEMBS.2011.6091417.

Detection of copy number variation using scale space filtering.

Author information

  • 1Department of Computer Engineering, Hallym University, Korea. jongkeun@hallym.ac.kr

Abstract

This study proposes a novel CNV detection algorithm based on scale space filtering. It uses Gaussian filter for the convolution with a scale parameter. The range of the scale parameter is adjusted according to the coverage level of read data. The position of a CNV region is determined through a coarse and a fine searches over the scales. The results showed low dependency of the performance of the proposed method on the coverage level compared to the conventional methods. The results also showed that the proposed method outperforms the conventional methods by 63.29 ~ 73.57 %.

PMID:
22255597
[PubMed - indexed for MEDLINE]
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