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Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5153-6. doi: 10.1109/IEMBS.2011.6091276.

A landmark-free framework for the detection and description of shape differences in embryos.

Author information

  • 1Department of Electrical Engineering, University of Washington, Seattle, Washington, USA.

Abstract

This paper introduces a new method to quantify and characterize shape changes during early facial development without the use of landmarks. Landmarks are traditionally used in morphometric analysis, but very few can be identified reliably across all stages of embryonic development. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images. Low and mid-level features are extracted from the deformable vector field to find regions of organized differences that are biologically relevant. These methods are shown to detect regions of difference when evaluated on chick embryo images warped with small magnitude deformations in regions critical to midfacial development.

PMID:
22255499
[PubMed - indexed for MEDLINE]
PMCID:
PMC3261520
Free PMC Article

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