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Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4657-60. doi: 10.1109/IEMBS.2011.6091153.

Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms.

Author information

  • 1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA. eric.sobie@mssm.edu

Abstract

Mathematical models are used extensively in studies of cardiac electrophysiology and arrhythmia mechanisms. Models can generate novel predictions, suggest experiments, and provide a quantitative understanding of underlying mechanisms. Limitations of present modeling approaches, however, include non-uniqueness of both parameters and the models themselves, and difficulties in accounting for experimental variability. We describe new approaches that can begin to address these limitations, and show how these can provide novel insight into mathematical models of cardiac myocytes.

PMID:
22255376
[PubMed - indexed for MEDLINE]
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