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Invest Ophthalmol Vis Sci. 2012 Mar 9;53(3):1169-76. doi: 10.1167/iovs.11-8259. Print 2012 Mar.

Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial.

Collaborators (305)

Jaffe GJ, Cusick M, Ehlers J, Srivastava S, Fernandes A, Gibbs D, Martin DF, Dunn JP, Arnold E, Boring J, Brown DM, Livingston AG, Nolan K, Reed T, Belair ML, Bolton SG, Brodine JB, Brune LM, Galor A, Jacobowitz A, Kapoor M, Kedhar S, Leder HA, Morton Y, Peters GB, Stevenson PS, Tarver-Carr M, Wang Y, Kim S, Foster CS, Contero A, Bruner L, Fitzpatrick K, Hinkle DM, Johnson J, Marvell D, Pinto J, Acevedo S, Anzaar F, Cesca T, Lebron KQ, Patel CM, Sprague J, Yilmaz T, Sen HN, Cunningham D, Hayes D, Koutsandreas D, Krishnadev N, Larson T, Meleth AD, Mercer R, Nussenblatt RB, Sherry PR, Short GL, Smith W, Temple A, Latkany PA, Badamo J, Gallardo J, Lorenzo-Latkany M, Masini R, Morell S, Nour A, Sanchez M, Steinberg K, Stawell RJ, Breayley L, Ewing J, D'Sylva C, Hodgson L, Koukouras I, Lim L, Ling C, McIntosh R, Newton A, Smallwood R, Zamir E, Merrill PT, Hulvey P, Kernbauer E, Toennessen S, Voskuil-Marre DL, Wang RC, Aguado H, Arceneaux S, Cummings K, Fish GE, Gray K, Hesse N, Howden S, Jaramillo D, Mackens M, Mutz K, Sanchez B, Lightman S, Stubbs T, Taylor S, Towler H, Holland GN, Almanzor RD, Castellanos J, Hubschman JP, Johiro AK, Kapamajian MA, Levinson RD, Ransome SS, Freeman WR, Cochran DE, Kozak I, Nguyen V, Oster SF, Powell D, Margolis TP, Acharya N, Clay D, Khouri CM, Lew M, Stewart J, Wong IG, Goldstein DA, Niec M, Tessler HH, Davis JL, Albini T, Pacini A, Pinto DA, Elner SG, Brown R, Fournier L, Gothrup JR, Hackel R, Hesselgrave M, Prusak R, Saxe SJ, Kempen JH, Berger J, DuPont J, Grand S, McCall D, Maguire AM, Weeny L, Will D, Xu W, Pavan PR, Leto J, Mayor L, McDonald K, Pautler SE, Saxon W, Soto J, Fawzi A, Cisneros L, Corona E, Douglass J, Eliott D, Padilla M, Rao NA, Vitale A, Bernstein PS, Carlstrom B, Gilman J, Hanseen S, Morris P, Ramirez D, Wegner K, Sheppard JD, Anthony B, Franklin L, Hamelin K, Scoper SV, Fernandez J, Felix-Ken L, Marx R, Kim RY, Benz MS, Brown DM, Chen E, Fish RH, Hay S, Majo J, Shawver L, Wong TP, Rao K, Weeks R, Jabs DA, Altaweel MM, Holbrook JT, Kempen JH, Kurinij N, Jabs DA, Almanzor RD, Altaweel MM, Brown D, Dunn JP, Gilman J, Holbrook JT, Holland GN, Kempen JH, Kim RY, Kurinij N, Prusakowski N, Thorne JE, Wittes J, Barlow WE, Hochberg M, Holbrook JT, Jabs DA, Kurinij N, Lyon AT, Altaweel MM, Palestine AG, Simon LS, Smith H, Kempen JH, Dunn JP, Jaffe GJ, Thorne JE, Acharya N, Jabs DA, Kempen JH, Latkany PA, Nussenblatt RB, Vitale A, Almanzor RD, Alexander J, Boring JA, Gibbs D, Lee S, Thorne JE, Friedman DS, Adler A, Burke A, Holbrook JT, Katz J, Kempen JH, Prusakowski N, Reed S, Thorne JE, Sugar EA, Drye L, Frick K, Holbrook JT, Katz J, Louis T, Natta ML, Jabs DA, Hilal Y, Nieves MA, Pascual K, Slutsky JS, Kempen JH, Holbrook JT, Adler A, Alexander J, Boring J, Burke A, Collins K, Dodge J, Drye L, Ewing L, Frick K, Friedman DS, Jackson R, Katz J, Lears A, Livingston H, Louis T, Meinert C, Meinert J, Morrison V, Nowakowski D, Prusakowski N, Shade D, Smith R, Steuernagle K, Sugar EA, Thorne JE, Tonascia J, Natta ML, Zheng R, Altaweel MM, Benz WK, Chambers G, Christianson DJ, Domalpally A, Freund J, Gama V, Gangaputra S, Glander KE, Goulding A, Joyce JM, Kruse CN, Myers DJ, Reed S, Reimers JL, Remm A, Susman RA, Thayer D, Treichel E, Warren KJ, Watson SM, White JK, Wilhelmson T, Kurinij N.

Author information

  • 1Department of Health Policy and Management, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. kfrick@jhsph.edu

Abstract

PURPOSE:

To evaluate the associations between visual acuity and self-reported visual function; visual acuity and health-related quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis.

METHODS:

Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and EuroQoL EQ-5D questionnaires were obtained at enrollment in a clinical trial of uveitis treatments. Multivariate regression and Spearman correlations were used to evaluate associations between visual acuity, vision-related function, and health-related QoL.

RESULTS:

Among the 255 patients, median visual acuity in the better-seeing eyes was 20/25, the vision-related function score indicated impairment (median, 60), and health-related QoL scores were within the normal population range. Better visual acuity was predictive of higher visual function scores (P ≤ 0.001), a higher SF-36 physical component score, and a higher EQ-5D health utility score (P < 0.001). The vision-specific function score was predictive of all general health-related QoL (P < 0.001). The correlations between visual function score and general quality of life measures were moderate (ρ = 0.29-0.52).

CONCLUSIONS:

The vision-related function score correlated positively with visual acuity and moderately positively with general QoL measures. Cost-utility analyses relying on changes in generic healthy utility measures will be more likely to detect changes when there are clinically meaningful changes in vision-related function, rather than when there are only changes in visual acuity. (ClinicalTrials.gov number, NCT00132691.).

PMID:
22247489
[PubMed - indexed for MEDLINE]
PMCID:
PMC3339901
Free PMC Article
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