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Curr Opin Pediatr. 2012 Apr;24(2):225-32. doi: 10.1097/MOP.0b013e3283504f88.

Clinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents in children.

Author information

  • 1Division of Emergency Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. cyril.sahyoun@childrens.harvard.edu

Abstract

PURPOSE OF REVIEW:

Procedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department.

RECENT FINDINGS:

Numerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized.

SUMMARY:

We review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.

PMID:
22245909
[PubMed - indexed for MEDLINE]
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