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Trends Mol Med. 2012 Mar;18(3):145-55. doi: 10.1016/j.molmed.2011.12.002. Epub 2012 Jan 12.

Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty.

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  • 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Surgery, University of Oxford, Headington, Oxford OX3 7LD, UK.

Abstract

Theoretical, desirable features of second-generation metal-on-metal (MoM) hip prostheses have led to their widespread use. However, the bearing surfaces, consisting of complex cobalt-chromium alloys, are subject to wear and the release of cobalt and chromium (CoCr) nanoparticles. These nanoparticles can reduce cellular viability, induce DNA damage, lead to chromosomal aberrations, and possibly stimulate increased metal hypersensitivity. Clinically, the effects can be both local (soft-tissue reactions) and systemic (arthroprosthetic cobaltism). This review assesses the literature concerning the in vitro and in vivo cytotoxic, genotoxic, and immunotoxic effects of CoCr wear particles, which is increasingly important in view of the large number of MoM arthroplasties performed.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22245020
[PubMed - indexed for MEDLINE]
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