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Chem Commun (Camb). 2012 Feb 18;48(15):2131-3. doi: 10.1039/c2cc17192a. Epub 2012 Jan 13.

Ternary resin-bound Dynamic Combinatorial Chemistry.

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  • 1Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.

Abstract

The ability to carry out simultaneous orthogonal exchange chemistries has opened new opportunities for increasing the numerical and structural diversity accessible to Dynamic Combinatorial Chemistry. We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity.

This journal is © The Royal Society of Chemistry 2012

PMID:
22240966
[PubMed - indexed for MEDLINE]
PMCID:
PMC3652255
Free PMC Article

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