Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Cell Endocrinol. 2012 Apr 4;351(2):264-8. doi: 10.1016/j.mce.2011.12.016. Epub 2012 Jan 3.

Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency.

Author information

  • 1Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London (UCL) Institute of Child Health, University College London, London WC1N 1EH, United Kingdom.

Abstract

Lin28 proteins are emerging as important regulators of microRNAs in endocrine systems. Lin28a regulates primordial germ cell development and puberty timing in mice, whereas the related protein LIN28B is associated with age at menarche in genome-wide association studies in humans. Here, we studied expression of LIN28A and LIN28B in early human gonad development. LIN28A increased in the developing ovary between 6 and 9weeks post conception, but not in the developing testis. Immunohistochemistry demonstrated LIN28A in peripheral germ cells. LIN28B was expressed at lower levels in both tissues and did not increase with time. As disruption of Lin28a affects germ cell development in mice, LIN28A was considered a candidate gene for primary ovarian insufficiency (POI) in humans. However, no significant changes were found in 50 women studied. These findings show LIN28A is strongly expressed in germ cells during early human ovary development, but disruption of LIN28A is not a common cause of POI.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PMID:
22240064
[PubMed - indexed for MEDLINE]
PMCID:
PMC3314903
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk