J Infect. 2012 Mar;64(3):311-8. Epub 2012 Jan 2.
Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza.
Diaz E,
Martin-Loeches I,
Canadell L,
Vidaur L,
Suarez D,
Socias L,
Estella A,
Gil Rueda B,
Guerrero JE,
Valverdú-Vidal M,
Vergara JC,
López-Pueyo MJ,
Magret M,
Recio T,
López D,
Rello J,
Rodriguez A;
H1N1 SEMICYUC-CIBERES-REIPI Working Group (GETGAG).
Cobo P, Martins J, Carbayo C, Robles-Musso E, Cárdenas A, Fierro J, Fernández DO, Sierra R, Huertos MJ, Pozo JC, Guerrero R, Márquez E, Rodríguez-Carvajal M, Estella A, Pomares J, Ballesteros JL, Fernández Y, Lobato F, Prieto JF, Albofedo-Sánchez J, Martínez P, de la Torre MV, Nieto M, Castellanos MA, Sevilla G, Garnacho-Montero J, Hinojosa R, Fernández E, Loza A, León C, Arenzana A, Ocaña D, Navarrete I, Beryanaki MZ, Sánchez I, Avellanas ML, Lander A, de Arellano SG, Lacueva MI, Luque P, Serrano EP, Lázaro JF, González I, Maria Montón J, Regil PD, Iglesias L, González CP, Quiroga, García-Rodríguez A, Socias L, Ibánez P, Borges-Sa M, Socias A, Del Castilo A, Marcos RJ, Bonell JM, Amestarán I, Ruiz-Santana S, Díaz JJ, Sisón, Hernández D, Trujillo A, Regalado L, Lorente L, Martín M, Martínez S, Cáceres JJ, Suberviola B, Ugarte P, García-López F, Alonso AA, Pasilla A, Grande ML, Albaya A, Canabal A, Marina L, Simón A, Añón JM, Messa JB, Pueyo MJ, María del valle O, Ferreras Z, Macias S, Berezo JA, Varela JB, Ojeda A, Terrero AA, Ezpeleta FT, Paez Z, García A, Maria Catalán R, Ferrer M, Torres A, Cilloniz C, Barbadillo S, Cabré L, Baeza I, Rovira A, Alvarez-Lerma F, Vázquez A, Nolla J, Fernández F, Cervelló JR, Iglesia R, Mañéz R, Ballús J, Maria Granada R, Vallés J, Ortíz M, Guía C, Arméstar F, Páez J, Almirall J, Balanzo X, Rello J, Arnau E, Pérez M, Laborda C, Souto J, Palomar M, Catalán I, Maria Sirvent J, Ferri C, de Arbina NL, Badía M, Valverdú-Vidal M, Barcenilla F, Magret M, Esteban MF, Luna J, Maria Nava J, de Molina JG, Josic Z, Gurri F, Rodríquez A, Lisboa T, Pobo A, Trefler S, Díaz RM, Mesalles E, de Mendoza D, José JN, Fernández-Zapata A, Recio T, Arrascaeta A, García-Ramos MJ, Gallego E, Bueno F, Díaz M, Cordero ML, Pastor JA, Alvarez L, Coruña A, Vila D, Lamas AD, Pérez JB, Piquer MO, Merayo E, López-Ciudad VJ, Cañones JC, Vilaboy E, Chao JV, Saborido EM, González RJ, Freita S, Alemparte E, Ortega A, López AM, Canabal J, Ferres E, Monzón JL, Goñi F, Sáez Fdel N, Navalpotro MB, García-Torrejón MC, Pérez C, López D, Arnaiz L, Sánchez-Alonso S, Velayos C, del Río F, González MA, Martín MC, Maria Molina J, Montejo JC, Catalán M, Albert P, de Pablo A, Guerrero JE, Zurita M, Peyrat JB, Cerdá E, Alvarez M, Pey C, Rodríguez M, Palencia E, Caballero R, Vaquero C, Mariscal F, García S, Carrasco N, Prieto I, Liétor A, Ramos R, Galván B, Figueira JC, Soriano MC, Galdós P, Moreno BB, del Cabo F, Hermosa C, Gordo F, Algora A, Paredes A, Cambronero JA, Gómez-Rosado S, López LM, Esteban A, Lorente JA, Nin N, Martínez S, Abad FF, Martínez M, Butí SM, Rueda BG, García F, Macaya L, Maraví-Poma E, Urra IJ, Redin LM, Tellería A, Insansti J, González N, Marco P, Vidaur L, Santamaría B, Rodríguez T, Vergara JC, Amiano JR, Manzano A, Arenal CC, Olaechea PM, Martín H, Blanquer J, Valero RR, Belenger A, Altaba S, Alvarez-Sánchez B, Picos SA, Sánchez-Miralles A, Bonastre J, Palamo M, Cebrian J, Cuñat J, Romero B, Zaragoza R, Tormo C, Paricio V, Marques A, Sánchez-Morcillo S, Tormo S, Latour J, García MA, Ribas A.
Source
Critical Care Department, Hospital Sant Joan Despí Moisès Broggi, Jacint Verdaguer, 90, 08970 Sant Joan Despí, Barcelona, CIBERES, IISPV, Spain. emilio.diaz.santos@gmail.com
Abstract
OBJECTIVE:
During the first pandemic, some patients with pandemic (H1N1) 2009 influenza were treated with corticosteroids. The objective of this study was to assess the effect on survival of corticosteroid therapy in patients with pandemic (H1N1) 2009 influenza.
METHODS:
Prospective, observational, multicenter study performed in 148 ICU. Data were recorded in the GTEI/SEMICYUC registry. Adult patients with pandemic (H1N1) 2009 influenza confirmed by rt-PCR were included in the analysis. Database records specified corticosteroid type and reason for corticosteroid treatment.
RESULTS:
372 patients with the diagnosis of primary viral pneumonia and completed outcomes treated in an ICU were included in the database. Mechanical ventilation was used in 70.2% of the patients. 136 (36.6%) patients received corticosteroids after a diagnosis of primary viral pneumonia. Obesity (35.6% vs 47.8% p = 0.021) and asthma (7.6% vs 15.4% p = 0.018), were more frequent in the group treated with corticosteroids. A Cox regression analysis adjusted for severity and potential confounding factors found that the use of corticosteroid therapy was not significantly associated with mortality (HR = 1.06, 95% CI 0.626-1.801; p = 0.825).
CONCLUSIONS:
Corticosteroid therapy in a selected group of patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza does not improve survival.
Copyright © 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
- PMID:
- 22240033
- [PubMed - in process]
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