Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 2012 Mar;132(3 Pt 2):829-34. doi: 10.1038/jid.2011.400. Epub 2012 Jan 12.

Old and new: recent innovations in vaccine biology and skin T cells.

Author information

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02493, USA. tkupper@partners.org

Abstract

Memory is the hallmark of the adaptive immune system, and the observation that infectious diseases often lead to lifelong immunity in individuals who survive a first infection became the genesis for the development of vaccines. Immunization, which is the iatrogenic engineering of a protective memory immune response to a pathogen, became a standard part of medical care in the twentieth century, and has had an almost incalculable positive effect on human health and wellness. Vaccines to many, but by no means all, infectious diseases have been developed and are in common use. Smallpox vaccine, arguably the most effective vaccine in human history, was (and still is) delivered through disrupted epidermis in a process called scarification. Virtually all vaccines today are delivered by means of a hypodermic needle and syringe into muscle, in a process that bypasses the epidermis and dermis and their attendant innate and adaptive immune attributes. This article discusses vaccines in the context of the newly appreciated paradigm of tissue-resident memory T cells, and specifically discusses the role of these cells in skin and other epithelial interfaces with the environment in the maintenance of protective immunity.

PMID:
22237702
[PubMed - indexed for MEDLINE]
PMCID:
PMC3644944
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk