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Pigment Cell Melanoma Res. 2012 Mar;25(2):182-7. doi: 10.1111/j.1755-148X.2012.00971.x. Epub 2012 Feb 2.

Genetic and molecular characterization of uveal melanoma cell lines.

Author information

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Comprehensive Cancer Center, New York, NY, USA.

Abstract

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community.

Published 2012. This article is a US Government work and is in the public domain in the USA.

PMID:
22236444
[PubMed - indexed for MEDLINE]
PMCID:
PMC3288394
Free PMC Article
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