Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Genet. 2012 Apr;81(4):341-9. doi: 10.1111/j.1399-0004.2012.01843.x. Epub 2012 Feb 13.

The early-life social environment and DNA methylation.

Author information

  • 1Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada. moshe.szyf@mcgill.ca

Abstract

DNA methylation is a chemical modification of DNA that confers, upon identical sequences, different identities that are reflected in different gene expression programming. DNA methylation has a well-established role in cellular differentiation by providing a mechanism for one genome to express multiple phenotypes in a multicellular organism. Recent data point however to the possibility that in addition to the innate process of cellular differentiation, DNA methylation can serve as a genome adaptation mechanism, adapting genome function to changing environmental contexts including social environments. A critical time point for this process is early life when cues from the social and physical environments define lifelong trajectories of physical and mental health. DNA methylation and additional epigenetic modifications could therefore serve as molecular links between 'nurture' and 'nature'. Data that are consistent with this new role for DNA methylation as a mechanism for conferring an 'environment' specific identity to DNA will be discussed.

© 2012 John Wiley & Sons A/S.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk