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Heredity (Edinb). 2012 May;108(5):563-8. doi: 10.1038/hdy.2011.124. Epub 2012 Jan 11.

A brief note on the resemblance between relatives in the presence of population stratification.

Author information

  • 1Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143-0794, USA. ronnie.sebro@ucsf.edu

Abstract

Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.

PMID:
22234249
[PubMed - indexed for MEDLINE]
PMCID:
PMC3330693
Free PMC Article

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