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Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1145-50. doi: 10.1073/pnas.1118411109. Epub 2012 Jan 10.

Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation.

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  • 1Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

Abstract

A blastocyst will implant only when the uterus becomes receptive. Following attachment, luminal epithelial cells undergo degeneration at the site of the blastocyst. Although many genes critical for uterine receptivity are primarily regulated by ovarian hormones, Kruppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is persistently expressed in epithelial cells independently of ovarian hormones. Loss of uterine Klf5 causes female infertility due to defective implantation. Cox2 is normally expressed in the luminal epithelium and stroma at the site of blastocyst attachment, but luminal epithelial COX2 expression is absent with loss of Klf5. This is associated with the retention of the epithelium around the implantation chamber with arrested embryonic growth. These results suggest that Klf5 is indispensable for normal implantation.

PMID:
22233806
[PubMed - indexed for MEDLINE]
PMCID:
PMC3268277
Free PMC Article
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