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Arq Bras Cardiol. 2012 Feb;98(2):136-42. Epub 2012 Jan 9.

Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis.

[Article in English, Portuguese]

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  • 1Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil.

Abstract

BACKGROUND:

Resveratrol protects the cardiovascular system by a number of mechanisms, including antioxidant and anti-platelet activities.

OBJECTIVE:

To assess the potential anti-inflammatory and antiatherogenic effects of resveratrol using rabbits fed a hypercholesterolemic diet (1% cholesterol).

METHODS:

Twenty white male rabbits were selected and divided into two groups: control group (CG), 10 rabbits; and resveratrol group (RG), 10 rabbits. The animals were fed a hypercholesterolemic diet for 56 days. For the RG diet, resveratrol (2 mg/kg weight/day) was added from days 33-56.

RESULTS:

There was no significant difference in the total serum cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides between the groups. Of the CG, 70% had advanced aortic atherosclerotic lesions (types III, IV, V, or VI). All animals from the RG had mild aortic atherosclerotic lesions (types I or II, or no lesions). The intima area and the intima/media layer area ratio was significantly lower in the RG as compared to the CG (p<0.001). Positive areas for VCAM-1 molecules were lower in the RG (p=0.007). The MCP-1 and IL-6 concentrations were lower in the RG than the CG (p=0.039 and p=0.015, respectively).

CONCLUSION:

Resveratrol had significant anti-atherogenic and anti-inflammatory effects in an animal model with rabbits fed a hypercholesterolemic diet (1% cholesterol).

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PMID:
22231915
[PubMed - indexed for MEDLINE]
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