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Curr Opin HIV AIDS. 2012 Mar;7(2):99-105. doi: 10.1097/COH.0b013e32834f5cf2.

HIV treatment as prevention and HPTN 052.

Author information

  • 1Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. myron_cohen@med.unc.edu

Abstract

PURPOSE OF REVIEW:

This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published.

RECENT FINDINGS:

A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96%. The logistical challenges in preparing for and conducting such a trial were considerable.

SUMMARY:

HPTN 052 required many years of preparation, considerable collaboration between National Institute of Health and six pharmaceutical companies, and careful ongoing consideration of a large number of ethical issues. HPTN 052 revealed the magnitude of benefit when using antiretroviral therapy to prevent the transmission of HIV, and served as proof of a concept. The results have proven central to the development of new global HIV-prevention efforts.

PMID:
22227585
[PubMed - indexed for MEDLINE]
PMCID:
PMC3486734
Free PMC Article
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