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J Clin Neurosci. 2012 Feb;19(2):336-8. doi: 10.1016/j.jocn.2011.05.026. Epub 2012 Jan 9.

Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma.

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  • 1Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.


We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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