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Curr Opin Neurobiol. 2012 Apr;22(2):294-300. doi: 10.1016/j.conb.2011.12.005. Epub 2012 Jan 7.

Sequence learning and the role of the hippocampus in rodent navigation.

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  • 1Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.


The hippocampus has long been associated with navigation and spatial representations, but it has been difficult to link directly the neurophysiological correlates of hippocampal place cells with navigational planning and action. In recent years, large-scale population recordings of place cells have revealed that spatial sequences are stored and activated in ways that may support navigational strategies. Plasticity mechanisms allow the hippocampus to store learned sequences of locations that may allow predictions of future locations based on past experience. These sequences can also be activated during navigational behavior in ways that may allow the animal to learn trajectories toward goals. Task-dependent alterations in place cell firing patterns may reflect the operation of the hippocampus in associating locations with navigationally relevant decision variables.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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