J Infect Dis. 2012 Feb;205(4):535-539. Epub 2012 Jan 5.

Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke.

Worm SW, Kamara DA, Reiss P, Fontas E, De Wit S, El-Sadr W, D'Arminio Monforte A, Law M, Phillips A, Ryom L, Dabis F, Weber R, Sabin C, Lundgren JD; on behalf of the D:A:D Study Group.

Source

Copenhagen HIV Programme, University of Copenhagen, Denmark.

Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

PMID:: 22223855; [PubMed - as supplied by publisher]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: a 5-year cohort study. [Arch Intern Med. 2000]
Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: a 5-year cohort study.
Tsiodras S, Mantzoros C, Hammer S, Samore M. Arch Intern Med. 2000 Jul 10; 160(13):2050-6.
Oral erythromycin and the risk of sudden death from cardiac causes. [N Engl J Med. 2004]
Oral erythromycin and the risk of sudden death from cardiac causes.
Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM. N Engl J Med. 2004 Sep 9; 351(11):1089-96.
Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4. [Arch Intern Med. 2010]
Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4.
Lang S, Mary-Krause M, Cotte L, Gilquin J, Partisani M, Simon A, Boccara F, Costagliola D, Clinical Epidemiology Group of the French Hospital Database on HIV. Arch Intern Med. 2010 Jul 26; 170(14):1228-38.
Review Lopinavir/ritonavir: a review of its use in the management of HIV infection. [Drugs. 2003]
Review Lopinavir/ritonavir: a review of its use in the management of HIV infection.
Cvetkovic RS, Goa KL. Drugs. 2003; 63(8):769-802.
Review Combination of protease inhibitors for the treatment of HIV-1-infected patients: a review of pharmacokinetics and clinical experience. [Antivir Ther. 2001]
Review Combination of protease inhibitors for the treatment of HIV-1-infected patients: a review of pharmacokinetics and clinical experience.
van Heeswijk RP, Veldkamp A, Mulder JW, Meenhorst PL, Lange JM, Beijnen JH, Hoetelmans RM. Antivir Ther. 2001 Dec; 6(4):201-29.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemo...
Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke.
J Infect Dis. 2012 Feb;205(4):535-539. Epub 2012 Jan 5.

PubMed
Early clinical failure of the Birmingham metal-on-metal hip resurfacing is assoc...
Early clinical failure of the Birmingham metal-on-metal hip resurfacing is associated with metallosis and soft-tissue necrosis.
J Bone Joint Surg Br. 2009 Aug ;91(8):1025-30.

PubMed
Abstracts of the Third Birt-Hogg-Dubé Symposium. Maastricht, The Netherlands. Ma...
Abstracts of the Third Birt-Hogg-Dubé Symposium. Maastricht, The Netherlands. May 11-12th, 2011.
Fam Cancer. 2011 May ;10 Suppl 3:S103-16.

PubMed
Evaluation of blood donor deferral causes in the Trinidad and Tobago National Bl...
Evaluation of blood donor deferral causes in the Trinidad and Tobago National Blood Transfusion Service.
Transfus Med. 2010 Feb ;20(1):11-4. Epub 2009 Sep 24 .

PubMed
Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria.
Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria.
South Med J. 2011 Jan ;104(1):40-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke.

Source

Abstract

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information