Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Biotechnol. 2012 Oct;23(5):736-43. doi: 10.1016/j.copbio.2011.12.016. Epub 2012 Jan 3.

Synthetic biological approaches to natural product biosynthesis.

Author information

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, United States.

Abstract

Small molecules produced in Nature possess exquisite chemical diversity and continue to be an inspiration for the development of new therapeutic agents. In their host organisms, natural products are assembled and modified using dedicated biosynthetic pathways. By rationally reprogramming and manipulating these pathways, unnatural metabolites containing enhanced structural features that were otherwise inaccessible can be obtained. Additionally, new chemical entities can be synthesized by developing the enzymes that carry out these complicated chemical reactions into biocatalysts. In this review, we will discuss a variety of combinatorial biosynthetic strategies, their technical challenges, and highlight some recent (since 2007) examples of rationally designed metabolites, as well as platforms that have been established for the production and modification of clinically important pharmaceutical compounds.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22221832
[PubMed - indexed for MEDLINE]
PMCID:
PMC3418455
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk