Hum Pathol. 2012 Apr;43(4):467-80. Epub 2012 Jan 4.

Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications.

Papathomas TG, Venizelos I, Dunphy CH, Said JW, Wang ML, Campo E, Swerdlow SH, Chan JC, Bueso-Ramos CE, Weisenburger DD, Medeiros LJ, Young KH.

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Department of Pathology, Hippokration General Hospital of Thessaloniki, 54642 Thessaloniki, Greece.

Abstract

Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.

PMID:: 22221705; [PubMed - indexed for MEDLINE]

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