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Int J Radiat Biol. 2012 Apr;88(4):327-34. doi: 10.3109/09553002.2012.652727. Epub 2012 Feb 6.

The effects of proton radiation on the prothrombin and partial thromboplastin times of irradiated ferrets.

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  • 1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

PURPOSE:

To determine whether proton radiation affects coagulation.

MATERIAL AND METHODS:

Ferrets were exposed to solar particle event-like proton radiation at doses of 0, 25, 100, or 200 centigray (cGy), and dose rates of 50 cGy/minute (high dose rate or HDR) or 50 cGy/hour (low dose rate or LDR). Plasma was isolated from blood collected prior to radiation exposure and at 3-7 h post-radiation. Prothrombin time (PT) assays and activated partial thromboplastin time (aPTT) assays were performed as were mixing studies to determine the coagulation factors involved.

RESULTS:

HDR and LDR exposure led to statistically significant increases in PT values. It was determined that the HDR-induced increase in PT was due to Factor VII, while Factors II, V, and VII contributed to the LDR-induced increase in PT values. Only acute LDR exposure caused an increase in aPTT values, which remained elevated for 48 h post-irradiation (which was the latest time assayed in these studies). Mixing studies revealed that Factor IX contributed to the increased aPTT values. A majority of the animals exposed at the LDR had an International Normalized Ratio approaching or surpassing 2.0.

CONCLUSIONS:

PT/aPTT assays resulted in increased clotting times due to different coagulation factors, indicating potential radiation-induced coagulopathy.

PMID:
22221163
[PubMed - indexed for MEDLINE]
PMCID:
PMC3589974
Free PMC Article
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