Leuk Lymphoma. 2012 Feb 13. [Epub ahead of print]

Evolution of definitions of response, progression-free survival and event-free survival in front-line studies of chronic myeloid leukemia.

Source

Washington University of St. Louis , St. Louis, MO , USA.

Abstract

Standardized definitions of response and outcome are useful to evaluate study data, facilitate treatment guideline adherence and aid clinical decision-making. Although definitions of response in chronic myeloid leukemia (CML) have been standardized, definitions of disease progression have not been standardized, despite widespread adoption of the term to reflect development of advanced disease. This article reviews definitions of response and disease progression used for progression-free survival and event-free survival in key CML studies and implications for interpreting patient response. It is proposed that adherence to definitions of progression from the European LeukmiaNet may aid future research and therapeutic decision-making.

PMID:: 22220824; [PubMed - as supplied by publisher]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Front-line therapy with second-generation tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia: what is the optimal response? [J Clin Oncol. 2011]
Front-line therapy with second-generation tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia: what is the optimal response?
Jabbour E, Kantarjian HM, O'Brien S, Shan J, Quintás-Cardama A, Garcia-Manero G, Rios MB, Cortes JE. J Clin Oncol. 2011 Nov 10; 29(32):4260-5. Epub 2011 Oct 11.
Impact of treatment end point definitions on perceived differences in long-term outcome with tyrosine kinase inhibitor therapy in chronic myeloid leukemia. [J Clin Oncol. 2011]
Impact of treatment end point definitions on perceived differences in long-term outcome with tyrosine kinase inhibitor therapy in chronic myeloid leukemia.
Kantarjian H, O'Brien S, Jabbour E, Shan J, Ravandi F, Kadia T, Faderl S, Garcia-Manero G, Borthakur G, Cortes J. J Clin Oncol. 2011 Aug 10; 29(23):3173-8. Epub 2011 Jul 11.
Review Targeted chronic myeloid leukemia therapy: Seeking a cure. [Am J Health Syst Pharm. 2007]
Review Targeted chronic myeloid leukemia therapy: Seeking a cure.
Fausel C. Am J Health Syst Pharm. 2007 Dec 15; 64(24 Suppl 15):S9-15.
Review Targeted chronic myeloid leukemia therapy: seeking a cure. [J Manag Care Pharm. 2007]
Review Targeted chronic myeloid leukemia therapy: seeking a cure.
Fausel C. J Manag Care Pharm. 2007 Oct; 13(8 Suppl A):8-12.
Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis. [J Clin Oncol. 2010]
Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis.
Castagnetti F, Testoni N, Luatti S, Marzocchi G, Mancini M, Kerim S, Giugliano E, Albano F, Cuneo A, Abruzzese E, et al. J Clin Oncol. 2010 Jun 1; 28(16):2748-54. Epub 2010 May 3.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Evolution of definitions of response, progression-free survival and event-free s...
Evolution of definitions of response, progression-free survival and event-free survival in front-line studies of chronic myeloid leukemia.
Leuk Lymphoma. 2012 Feb 13. [Epub ahead of print]

PubMed
Histomorphometric and immunohistochemical analysis of human maxillary sinus-floo...
Histomorphometric and immunohistochemical analysis of human maxillary sinus-floor augmentation using porous β-tricalcium phosphate for dental implant treatment.
Clin Oral Implants Res. 2012 Jan 6. doi: 10.1111/j.1600-0501.2011.02396.x. [Epub ahead of print]

PubMed
Changes in soft tissues around immediate full-arch rehabilitations: a prospectiv...
Changes in soft tissues around immediate full-arch rehabilitations: a prospective study.
Clin Oral Implants Res. 2012 Jan 6. doi: 10.1111/j.1600-0501.2011.02394.x. [Epub ahead of print]

PubMed
[Asperger's syndrome: continuum or spectrum of autistic disorders?].
[Asperger's syndrome: continuum or spectrum of autistic disorders?].
Psychiatr Pol. 2011 Sep-Oct ;45(5):749-58.

PubMed
Cervical cancer in Osijek-Baranja County--possibilities for prevention.
Cervical cancer in Osijek-Baranja County--possibilities for prevention.
Coll Antropol. 2011 Sep ;35 Suppl 2:235-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Evolution of definitions of response, progression-free survival and event-free survival in front-line studies of chronic myeloid leukemia.

Source

Abstract

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information