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PLoS Comput Biol. 2011 Dec;7(12):e1002323. doi: 10.1371/journal.pcbi.1002323. Epub 2011 Dec 29.

Prediction of drug combinations by integrating molecular and pharmacological data.

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  • 1European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Abstract

Combinatorial therapy is a promising strategy for combating complex disorders due to improved efficacy and reduced side effects. However, screening new drug combinations exhaustively is impractical considering all possible combinations between drugs. Here, we present a novel computational approach to predict drug combinations by integrating molecular and pharmacological data. Specifically, drugs are represented by a set of their properties, such as their targets or indications. By integrating several of these features, we show that feature patterns enriched in approved drug combinations are not only predictive for new drug combinations but also provide insights into mechanisms underlying combinatorial therapy. Further analysis confirmed that among our top ranked predictions of effective combinations, 69% are supported by literature, while the others represent novel potential drug combinations. We believe that our proposed approach can help to limit the search space of drug combinations and provide a new way to effectively utilize existing drugs for new purposes.

PMID:
22219721
[PubMed - indexed for MEDLINE]
PMCID:
PMC3248384
Free PMC Article

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