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Sensors (Basel). 2010;10(6):5668-82. doi: 10.3390/s100605668. Epub 2010 Jun 4.

The role of PAS kinase in PASsing the glucose signal.

Author information

  • 1Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. julianne_grose@byu.edu

Abstract

PAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.

KEYWORDS:

PAS domain; PAS kinase; PASKIN; glucose sensor; metabolic syndrome; protein phosphorylation

PMID:
22219681
[PubMed - indexed for MEDLINE]
PMCID:
PMC3247726
Free PMC Article

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