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Mol Vis. 2011;17:3379-83. Epub 2011 Dec 24.

An association study of the COL1A1 gene and high myopia in a Han Chinese population.

Author information

  • 1Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People‚Äôs Hospital, Sichuan, China.

Abstract

PURPOSE:

Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population.

METHODS:

High myopia is defined by a spherical equivalent of less than or equal to -6.00 diopter sphere and an axial length longer than or equal to 26.0 mm in the affected eye. We genotyped rs2075555 and rs2269336 SNPs in COL1A1 in a Ha n Chinese group composed of 697 high myopia patients and 762 normal controls.

RESULTS:

Neither of the two SNPs showed significant association with high myopia (p(allelic)=0.252 for rs2075555, and p(allelic)=0.699 for rs2269336).

CONCLUSIONS:

Our study revealed that SNPs in COL1A1 are not significantly associated with high myopia in the Han Chinese population.

PMID:
22219633
[PubMed - indexed for MEDLINE]
PMCID:
PMC3247168
Free PMC Article
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